HaDeS: a Scalable Service Oriented Deployment System for Large Scale Installations

Building large computational facilities requires scalable and flexible deployment tools that can cope with massive loads. Classical installation methods are not very flexible, since they are usually limited in the number of OS supported, rely on transfer solutions that impose constraints on network topology, and do not scale very well. Here we describe HaDeS (Hardware Deployment System), a new deployment system for large scale installation designed to be agnostic with respect to the network topology and the OS deployed and to scale with the number of nodes being deployed.251-25

Correction to: Deep reinforcement learning for multi-objective placement of virtual machines in cloud datacenters

Page 2: Column 2, lines 2-4, previously read: "Specifically, we consider a decision maker that, after a proper training, is able to select the most suitable heuristic for compute the placement for each VM requested by end users"

HIL: designing an exokernel for the data center

We propose a new Exokernel-like layer to allow mutually untrusting physically deployed services to efficiently share the resources of a data center. We believe that such a layer offers not only efficiency gains, but may also enable new economic models, new applications, and new security-sensitive uses. A prototype (currently in active use) demonstrates that the proposed layer is viable, and can support a variety of existing provisioning tools and use cases.Partial support for this work was provided by the MassTech Collaborative Research Matching Grant Program, National Science Foundation awards 1347525 and 1149232 as well as the several commercial partners of the Massachusetts Open Cloud who may be found at http://www.massopencloud.or

Multi-wavelength astronomical searches for primordial black holes

If primordial black holes of O(1–100) M_⊙ constitute a significant portion of the dark matter in the Universe, they should be very abundant in our Galaxy. We present here a detailed analysis of the radio and X-ray emission that these objects are expected to produce due to the accretion of gas from the interstellar medium. With respect to previous studies, we relax the assumption of a monochromatic mass function, and introduce an improved treatment of the physics of gas accretion onto isolated, moving compact objects, based on a set of state-of-the-art numerical simulations. By comparing our predictions with known radio and X-ray sources in the Galactic center region, we show that the maximum relic density of primordial black holes in the mass range of interest is ~ 10^(−3) smaller than that of dark matter. The new upper bound is two orders of magnitude stronger with respect to previous results, based on a conservative phenomenological treatment of the accretion physics. We also provide a comprehensive critical discussion on the reliability of this bound, and on possible future developments in the field. We argue in particular that future multi-wavelength searches will soon start to probe the galactic population of astrophysical black holes

Multi-wavelength astronomical searches for primordial black holes

If primordial black holes of $\mathcal{O}(1-100) M_{\odot}$ constitute a significant portion of the dark matter in the Universe, they should be very abundant in our Galaxy. We present here a detailed analysis of the radio and X-ray emission that these objects are expected to produce due to the accretion of gas from the interstellar medium. With respect to previous studies, we relax the assumption of a monochromatic mass function, and introduce an improved treatment of the physics of gas accretion onto isolated, moving compact objects, based on a set of state-of-the-art numerical simulations. By comparing our predictions with known radio and X-ray sources in the Galactic center region, we show that the maximum relic density of primordial black holes in the mass range of interest is $\sim 10^{-3}$ smaller than that of dark matter. The new upper bound is two orders of magnitude stronger with respect to previous results, based on a conservative phenomenological treatment of the accretion physics. We also provide a comprehensive critical discussion on the reliability of this bound, and on possible future developments in the field. We argue in particular that future multi-wavelength searches will soon start to probe the galactic population of astrophysical black holes.Comment: 21 pages, 6 figures. Prepared for submission to JCA

A preliminary experiment combining marine robotics and citizenship engagement using imitation learning

In this paper, we describe a preliminary experiment of citizenship engagement in the context of marine robotics using imitation learning to train a controller that mimics human behavior. The experiment has been carried out during the Festival della Comunicazione in Camogli, Italy, in September 2019. In more detail, citizens have been asked to pilot a small, light, and safe autonomous surface vehicle in front of a crowded public beach with the goal of performing an S-shaped path. The trajectories and controls performed by non-expert human operators have been recorded with the aim of training an imitation system that, after collecting a sufficient number of trajectory-control pairs, has been able to drive the vehicle without human intervention. To learn the human behavior, echo state networks have been employed as approximating architectures. The resulting controller turned out to be very effective in successfully performing the considered experiment with a reduced amount of training trajectories by imitating the human behavior also in unknown situations. The success of this experiment may pave the way to new research processes where citizens are actively engaged. Copyright (C) 2020 The Authors

Multi-wavelength astronomical searches for primordial black holes

If primordial black holes of O(1–100) M_⊙ constitute a significant portion of the dark matter in the Universe, they should be very abundant in our Galaxy. We present here a detailed analysis of the radio and X-ray emission that these objects are expected to produce due to the accretion of gas from the interstellar medium. With respect to previous studies, we relax the assumption of a monochromatic mass function, and introduce an improved treatment of the physics of gas accretion onto isolated, moving compact objects, based on a set of state-of-the-art numerical simulations. By comparing our predictions with known radio and X-ray sources in the Galactic center region, we show that the maximum relic density of primordial black holes in the mass range of interest is ~ 10^(−3) smaller than that of dark matter. The new upper bound is two orders of magnitude stronger with respect to previous results, based on a conservative phenomenological treatment of the accretion physics. We also provide a comprehensive critical discussion on the reliability of this bound, and on possible future developments in the field. We argue in particular that future multi-wavelength searches will soon start to probe the galactic population of astrophysical black holes

Nidogen-1 is a novel extracellular ligand for the NKp44 activating receptor

The release of soluble ligands of activating Natural Killer (NK) cell receptors may represent a regulatory mechanism of NK cell function both in physiologic and in pathologic conditions. Here, we identified the extracellular matrix protein Nidogen-1 (NID1) as a ligand of NKp44, an important activating receptor expressed by activated NK cells. When released as soluble molecule, NID1 regulates NK cell function by modulating NKp44-induced IFN-\u3b3 production or cytotoxicity. In particular, it also modulates IFN-\u3b3 production induced by Platelet-Derived Growth Factor (PDGF)-DD following NKp44 engagement. We also show that NID1 may be present at the cell surface. In this form or when bound to a solid support (bNID1), NID1 fails to induce NK cell cytotoxicity or cytokine release. However, analysis by mass spectrometry revealed that exposure to bNID1 can induce in human NK cells relevant changes in the proteomic profiles suggesting an effect on different biological processes

NKp44-NKp44 Ligand Interactions in the Regulation of Natural Killer Cells and Other Innate Lymphoid Cells in Humans

Natural Killer (NK) cells are potent cytotoxic cells belonging to the family of Innate Lymphoid Cells (ILCs). Their most characterized effector functions are directed to the control of aberrant cells in the body, including both transformed and virus-infected cells. NK cell-mediated recognition of abnormal cells primarily occurs through receptor-ligand interactions, involving an array of inhibitory and activating NK receptors and different types of ligands expressed on target cells. While most of the receptors have become known over many years, their respective ligands were only defined later and their impressive complexity has only recently become evident. NKp44, a member of Natural Cytotoxicity Receptors (NCRs), is an activating receptor playing a crucial role in most functions exerted by activated NK cells and also by other NKp44+ immune cells. The large and heterogeneous panel of NKp44 ligands (NKp44L) now includes surface expressed glycoproteins and proteoglycans, nuclear proteins that can be exposed outside the cell, and molecules that can be either released in the extracellular space or carried in extracellular vesicles. Recent findings have extended our knowledge on the nature of NKp44L to soluble plasma glycoproteins, such as secreted growth factors or extracellular matrix (ECM)-derived glycoproteins. NKp44L are induced upon tumor transformation or viral infection but may also be expressed in normal cells and tissues. In addition, NKp44-NKp44L interactions are involved in the crosstalk between NK cells and different innate and adaptive immune cell types. NKp44 expression in different ILCs located in tissues further extends the potential role of NKp44-NKp44L interactions